Wednesday, September 16, 2015

Bacteriophages -- a new solution to antibiotic resistance?

Prevention magazine had an article by Koren Wetmore in the February 2015 edition that described "The Natural Superbug Cure" that no one is telling you about.  It is about Bacteriophages.  Discover Magazine also had a good article about it.  Phage Therapy is the use of specialized viruses to attack and kill disease-causing bacteria.
The use of bacteriophages to cure diseases was done a lot in Russia prior to the development of antibiotics.  Antibiotics were easier to use, and seemed safer at the time.  Since the introduction of the first antibiotics, many other antibiotics have been developed to target specific types of bacteria.  However the bacteria have developed resistance to many of the antibiotics.  It is clear that by developing more phage therapies, we can bypass that antibiotic resistance and cure some diseases that could not be cured by antibiotics.  Also, if we can hone the process and make it efficient enough, we could use phage therapy as a 'mainstream' form of fighting disease and prevent the bacteria from becoming resistant to the antibiotics.  Of course, there is also the possibility that bacteria can develop a resistance or "immunity" to the phage viruses as well.
From what I've read, I think the Government should put some significant resources into the development of phage therapy.  Others seem to think so too.   See this article in Frontiers  I see one of the problems with continuing the development of phage therapy is that it would be difficult to get a pharmaceutical company interested in developing the technology.  It could take hundreds of millions of dollars to develop, test, and get FDA approval for new types of phage therapies.  But the drug company would probably not be able to patent the idea, or get a reasonable return on the huge investment.  In situations like this, the only solution is to use public funds to develop the technology.  To be even more effective, it may require many countries to get together to share in the cost of development of the technology.  

How to Live to 100?



I saw this article by Henry S Lodge on the front page of the September 15, 2015 issue of Bottom Line Personal that explains how to improve our chances to live to 100. It is a good article, and I'm glad that Bottom Line made it available online to everyone. Dr. Henry S. Lodge is a well respected internist, who has been ranked as one of the Best Doctors in America by Castle Connolly, and he has written several books. In this article he makes several good recommendations, but it appears that the one he thinks is most important is for us to exercise! I feel like I've exercised through high school & college (cross country), then had to maintain a fitness program through 27 years of military. I sort of thought that when I hit age 70, I could slack off a bit. But Dr Lodge says "Exercise more as you get older".. He says that everyone should exercise hard at least five days a week -- but if you are 50 or older you should make it six days a week! I guess that if we do get to live to 100, we'll finally get to rest in our "final resting place."...


I also listened to a good podcast from the "Health Report" with Norman Swan about the best exercise to do to reduce dementia risk. (Link also has transcript of podcast)  In the podcast, Norman interviewed Nicola Lautenschlager who's a professor of old age psychiatry at University of Melbourne. The professor presented evidence that regular aerobic exercise does seem to slow down the development of dementia and alzheimer's disease. He says that dementia and alzheimer's disease starts in the body 30 years prior to showing symptoms, so that exercise and other "environmental factors" can have a long time to work to either accelerate or slow down the progress of the diseases.  His recommendation is for "older people" to exercise 150 minutes per week, and that if we walk, it should be at a fast pace to get our heart rate up and blood pumping!